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Plasma vitamin E levels were measured, as were confounders including lower extremity muscle strength, cognitive function, diseases and factors related to vitamin E metabolism.

Age- and gender-adjusted levels of vitamin E decreased gradually from the nonfrail to frail group, with participants in the highest vitamin E tertile one third less likely to be frail than those in the lowest tertile.

The study appeared in The Journals of Gerontology Series A: Biological Sciences and Medical Sciences (61:278-83, 2006).

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